Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach
Multiple myeloma (MM) is an incurable clonal plasma cell malignancy.Subsets of patients have high-risk features linked with dismal outcome.Therefore, the need for effective therapeutic options remains high.Here, we used bio-informatic tools to identify novel targets involved in DNA repair and epigenetics and which are associated with high-risk myel